Камрад
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Beta-pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes.
Monobe M, Arimoto-Kobayashi S, Ando K.
Division of Heavy-ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan. [email]monobe@nirs.go.jp[/email]
We previously found that drinking beer reduces chromosome aberrations in blood lymphocytes that were collect and irradiated in vitro. In this study, human whole-blood was in vitro exposed to 200kVp X-rays or 50keV/microm carbon ions in the presence or absence of beer, ethanol and beta-pseudouridine (one of the beer components). All three agents reduced the chromosome aberrations (dicentric) caused by either X-rays or carbon ions of 4Gy. The maximum protection for X-rays by ethanol, beer and beta-pseudouridine was 64, 26 and 34%, respectively, while the maximum protection for carbon-ion by ethanol, beer and beta-pseudouridine was 22, 26 and 32%, respectively. It is concluded that beta-pseudouridine, a nucleoside present in tRNA, is a potent protector against damage caused by radiation with direct and indirect actions.
PMID: 12834758 [PubMed - indexed for MEDLINE]
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